Sentence examples for grade of activation from inspiring English sources

We also observed a higher number of rolling leukocytes (flux) in cryab - /- mice, indicating a lower grade of activation.

Each cell of the immune system shows a characteristic expression of cell surface molecules depending on the grade of activation or suppression.

Moreover, the anti-apoptotic effect of platelets is further increased and dependent on their grade of activation, suggesting potential involvement of platelet-derived mediators.

In macrophages and dendritic cells, the corresponding lipopolysaccharides reproduced these grades of activation, and binding of O. anthropi lipopolysaccharide to the TLR4 co-receptor MD-2 and NF-κB induction laid between those of B. abortus and enteric bacteria lipopolysaccharides.

We also calculated the grades of activation of CTNNB1, as previously reported [ 40].

When correlating histologic subtype and grade to activation of the BMI-1-driven signature in external gene expression data, activation of this signature confirmed it to be significantly correlated to non-endometrioid histologic subtype (P=0.02) and high histologic grade (grade 3) (P=0.001).

Furthermore, recent studies suggest that graded hedgehog signalling results in graded levels of activation of Gli protein, and hence concentration-dependent target gene activation [13].

When compared to the Luminal A subtype, Luminal B tumors often have lower expression levels of ERα or ER-regulated genes, higher tumor grade, activation of growth factor receptor signaling pathways and reduced sensitivity to chemotherapy than Luminal A tumors [ 53].

STAT3 is constitutively activated in 60% of primary high-grade/malignant gliomas and the extent of activation correlates positively with glioma grade.

The receptor tyrosine kinase (RTK -RAS-phosphoinositide 3-kinase (PI3K) pathway is activated in 88% of GBM tumoRTK -RAS-phosphoinositideGA, 2008), and in loweRTK -RAS-phosphoinositideon is predictive of a poor outcome (McBride et al., 2010).

Possible candidates are chronic 'low grade' activation of the innate immune system [ 13, 14] (which may start early in life [ 15- 17] and be influenced by cumulative effects of socioeconomic status over the life course [ 18]), insulin resistance and endothelial dysfunction [ 19, 20].