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When concomitant cytological and histological results were available, the highest histological grade of abnormality was used for the final diagnosis.
All results are presented based on the local histopathology and the highest grade of abnormality seen in the biopsy or treatment specimen was used.
We included any abnormal Pap smear after treatment in the group classified as persistence, that is any grade of abnormality and any Pap smear after treatment.
Furthermore, most ORs show a dose response (for each health outcome, more heat interference associates more strongly with a given grade of abnormality).
A mild smear corresponds to a higher grade of abnormality than a BNA smear; however, there was no relation between smear status and HADS anxiety score.
All analyses were based on a centrally reviewed histopathology and took the highest grade of abnormality seen in the biopsy or treatment specimen within 9 months of the initial base-line visit as the final diagnosis.
Similar(51)
The cohort indicator variable included in the combined analysis suggests a slightly lower prevalence of all three grades of abnormality in the retrospective cohort, although the difference was statistically significant only for lesser abnormality (retrospective: prospective OR 0.88, CI 0.81 0.96).
Moreover, the available studies have been limited in terms of size, by a lack of distinction between different grades of abnormality, or by confounding by management/follow-up (Bell et al, 1995; Maissi et al, 2004).
This was classified as low (n=10) and high (n=7) grade depending on the degree of abnormality present.
Data on the prevalence of cervical HPV genotypes in Australia by age and by grade of cytological abnormality are sparse.
Multiple infections with high-risk genotypes were more frequent than single infections regardless of the grade of cytological abnormality.
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