A first version of recommendations was elaborated using the GRADE method (Grade of Recommendation, Assessment, Development and Evaluation) [ 7, 8].
The GRADE method (Grading of Recommendations, Assessment, Development, and Evaluation) provides a tool for rating the quality of evidence for systematic reviews and clinical guidelines.
The GRADE method (Grading of Recommendations, Assessment, Development and Evaluation) aims to provide a tool for rating the quality of evidence (particularly for effectiveness) and grading the strength of recommendations (1, 2).
The evidence level of the primary outcomes will be analysed through the Grading of Recommendations Assessment Development and Evaluation (GRADE) method.
In cases of very high risk of bias, the grade of evidence should be decreased by three grades (e.g. from high level to very low level) instead of decreasing by only two grades, as suggested by the GRADE method.
A monodisciplinary panel was formed to define a restricted number of clinical questions, develop specific search strategies and critically appraise the literature using the grading of recommendations assessment, development, and evaluation (GRADE) method.
Kyrch et al.'s review, according to the GRADE method, started from a "low" quality level, while Prodromos et al.'s review, including case series with historic (non-concurrent) controls, started from a "very low" quality level.
The GRADE method was used to analyze the allograft question.
The GRADE method of assessment was chosen for ranking the evidence [3].
The methodology for this document is based on the GRADE method http://www.gradeworkinggroup.org//links.htm.htm
