Exact(1)
Compared to a traditional severity grade marker neopterin (R = 0.4105, P = 1.12E-03), any of identified proteins showed better potential to be utilized as CSF disease state biomarkers.
Similar(59)
By examining the expression pattern of Oncotype DX and Mammaprint profiles, as well as genetic grade markers proposed by Ivshina et al. [ 34], across all biclusters, we found that the expression patterns of these gene markers were associated with two broad groups of patients with differential clinical outcomes (see Figure 5 (A)).
The search for new grading markers is necessary to improve personalized therapies in a devastating disease like high-grade brain tumors.
It was shown in wheat [ 26] that occasional scoring errors occur most often for low-grade markers, and that most of these can be filtered out by adjusting quality parameters or call rate.
Besides its association with the nuclear grade, the marker D9S171 also showed a correlation with the antigen Ki-67 (Additional file 4).
The alanine racemase gene dal is involved in the conversion of d-alanine and l-alanine (Bron et al. 2002), and d-alanine is not a common ingredient of large-scale fermentation media (Nguyen et al. 2011); the dal gene thus has considerable potential as a food-grade selection marker in B. subtilis.
Elevated plasma suPAR concentration is associated with increased mortality in various patient groups, and it is speculated that suPAR is a low-grade inflammation marker reflecting on disease severity.
A positive correlation of vaspin with both insulin resistance and C-reactive protein, as a low-grade inflammatory marker, in the presence of metabolic abnormalities has been observed as well [ 38, 39].
Since human breast cancers are clustered into several phenotypes (subtypes) based on grade, molecular-markers and micro-array studies, a good animal model for a subtype is one which mimics most of the subtype characteristics – morphology, molecular markers, metastatic pattern, grade, hormone-dependency, parity/pregnancy-status etc. [ 2, 3].
Tissue arrays of breast invasive ductal carcinomas (75 cores/150 cores; BR1504, Biomax, Rockville, MD, USA) with known TNM, pathologic grade and markers (ER, PR, Her2 and Ki67) were stained with antibodies to p53 (DO-1, Santa Cruz Biotechnology) or p326-HSF1 (Epitomics, Burlingame, CA, USA).
Usually, food-grade selection markers can be classified as dominant markers or complementation markers (de Vos 1999).
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