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Case report forms captured all grade ≥3 toxicities, any grade neuropathy or edema, and any grade event resulting in dose reduction or delay.
Compared with imatinib, bosutinib was associated with a longer median time to first event (174 vs. 43 days) and a shorter median (any grade) event duration (22.5 vs. 85 days).
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RA treatments lead to a reduction of the absolute incidence of higher grade events.
High grade events (Common Toxicity Criteria grades 3 to 5) were reported inconsistently in the articles, and the information regarding attribution to investigational drugs was incomplete.
Invites to (admittedly low-grade) events had increased.
The most common all-grade events were epistaxis (n=9; 13%), hypertension (n=8; 12%) and proteinuria (n=8; 12%).
Patients receiving bevacizumab had an overall incidence of all-grade ATEs of 3.3%, whereas the incidence of high-grade events was 2%.
Capecitabine dose was reduced by 25% for patients who experienced a second occurrence of a given grade 2 event or any grade 3 event.
Capecitabine doses were reduced by 50% to 500 mg m−2 twice daily for patients who experienced a third occurrence of a given grade 2 event, a second occurrence of a given grade 3 event, or any grade 4 event.
Capecitabine doses were reduced by 50% for patients who experienced a third occurrence of a given grade 2 event, a second occurrence of a given grade 3 event, or any grade 4 event.
The grade 4 event and 2 of the grade 3 events (pain) were not attributed to the study drugs or procedures by the study investigators.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com