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Apparent diffusion coefficient has emerged as a method for identifying high grade central nervous system tumors [ 11– 13].
The resulting mammary tumours were characterised by high histological grade, central necrotic areas and expression of basal-like markers.
Even when adjusting for the effects of tumour size, nodal status, grade (central) and Ki67 expression, amplification of CCND1 was significantly associated with an increased risk of recurrence (HR = 1.61; 95% CI, 1.08 to 2.41; P = 0.03) (Table 2).
In univariate Cox analysis, age, smoking status, TNM classification, tumour grade, central tumour and haemoptysis were all statistically significant predictors for OS (P=0.003, 0.023, <0.001, <0.001, <0.001, <0.001, respectively).
The contribution of cyclin D1 protein expression was analysed by the change in likelihood ratio chi-squared test (one degree of freedom) univariately and multivariately, in addition to a model with tumour size, nodal status, grade (central) and Ki67 expression, for all patients and nonamplified patients.
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Surgical treatment of low-grade central CS has been a subject of debate for a long time.
Deformation character also varies from upright open folding in amphibolite facies domains in the north, upright tight chevron folding in a low-grade central domain, to a high-grade domain of tight to isoclinal inter-folded basement and cover, with inclination decreasing towards the south.
The aetiology of high-grade central osteosarcoma in young patients is elusive.
No low-grade central osteosarcoma and no Pagetic osteosarcomas exhibited FGFR1 gene amplification.
For 25 pre-operative biopsies from high-grade central osteosarcomas, we obtained good-quality genome-wide expression data.
An important characteristic of high-grade central nervous system tumors is the presence of massively upregulated protein kinase C (PKC) when compared to normal glia [ 16, 17].
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