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Because grading system adopted in the external dataset was distinct from that in the discovery set [21] [23], we could not make a simple comparison of malignant grade between the two datasets.
Immunostainings for Ki67 and quantification of positive cells showed no difference in tumors of the same grade between the two groups (data not shown) further supporting the in vitro data that HRG did not seem to have a direct effect on glial cell proliferation.
There was no difference in the distribution of histological grade between the two groups (P = 1).
The concordance in the assessment of tumor grade between the two pathologists was moderate (kappa 0.53, 95% CI 0.49 0.59).
However a more sensitive test comparing the worst recorded mucositis grade between the two arms was statistically significant (P = 0.009).
Liver biopsy assessment did not detect any differences in steatosis grade between the two treatment arms (Table 4).
Similar(47)
There was a significant difference in the grade between the three groups.
The recurrence score also provided significant information beyond tumour grade, despite the low levels of concordance in assessment of grade between the three pathologists in the study (43% overall).
Reliability in assessing kappa levels for CONSORT grading between the two reviewers measured 0.89.
There was no significant difference in grades between the two groups (Table 2).
Comparison of RACK1 grading between the two groups resulted in a statistical difference (1 ± 0 vs. 0.2 ± 0.36 respectively; P < 0.001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com