Adverse events were selected for inclusion in the model by grade of severity and frequency of occurrence by event and treatment arm, according to the following rules: all treatment-related adverse events grade 3 4, and adverse events that occurred from the start of the study and 28 days after the last cycle of first-line treatment inclusively.
Immunohistochemical (IHC) grading based on intensity and frequency of staining results was performed by two independent investigators without knowledge of the patients' clinicopathological features.
Once a system for toxicity grading has been chosen, a toxicity rules algorithm is developed for the proposed study, taking into account toxicity grading, severity/seriousness, reversibility, "expectedness" and frequency.
The age and sex of patients, treatment groups, clinical characteristics at randomization, maximum haematological toxicity grades attained during treatment and frequency of toxicity symptoms are shown in Tables 1 and 2. The presence of B symptoms was associated with disease stages 3 or 4, performance levels 2 4, elevated LDH and positive bone marrow assessments (Table 3).
In contrast, the frequency of p53 accumulation increased with grade and stage as did the frequency of staining for the proliferation marker Ki67.
The comparisons between three depression groups showed that LOD group had lower MMSE and SLE, higher LSNS scores, higher WMH grade, higher frequency of SBI, and microbleeds, especially lobar microbleeds and microbleeds in the left hemisphere than EOD group, whereas the corresponding values of POD group were in a mediate position (details not shown).
Mice were graded blindly for arthritis severity and frequency.
Also shown are the most commonly implicated drug subgroups (at ATC level 4 or at level 3 in some instances where the whole group is implicated) with the distribution of grades of severity of ADEs and frequency of hospitalisation.
Birth weight was weakly positively correlated with the number of different types of sports activities (r = 0.02, p = 0.039) but there were no other associations between birth weight or infant growth and PE grade or frequency of sports participation.
