Sentence examples for gr substitution from inspiring English sources
Sm2CPA and Pp2CPA show GN and an IV substitutions and Sm2CPB, which is encoded by a presumably nonexpressed or only weakly expressed gene, has a GR substitution.
Likewise, we have previously reported that in melanoma guanines at GRA motifs undergo ~twofold more frequent substitutions than guanines at GR(C|T|G) motifs (Bacolla et al. 2013).
Although the influence of substitutions at the HNF4 R188 or GR P188, or still any other DBD 188 position over the HRE specificity has still not been systematically checked, such structural analysis, taken all together, corroborates that residue substitutions at the set 3 of the correlation network could act in a concerted way to adapt the DBD positioning to aberrant DNA contexts.
The main difference is the absence of conventional GR and TR in these parasites, and the substitution of both enzymes by TGR as a sole redox "wire".
Control alanine/phenylalanine substitutions of Hop did not affect GR activation (Fig 3F).
By contrast, WAP from GR differs from WAP-A by three amino acid substitutions (L11R, P35Q and M90T), the first one being located in the signal peptide.
As it is usual for the 3-ketosteroid receptor subclass, GR presents the pattern C GSCK V in its P-box, with substitutions at the three principal positions that significantly modify the stereochemical characteristics of this segment.
Control alanine substitutions of Sti1 did not lead to a decrease of GR activation except for S95A (Fig 3E).
Gr is the set of rules rτ obtained by applying, to each rule r ∈ π, all possible substitutions τ from the variables in r to elements of U π.
This suggested that mineralocorticoid sensitivity was evolutionarily plastic and may have resulted from a small number of amino acid substitutions in the GRs rather than overall sequence homology.
