Highly specific receptor interactions (i.e., ER, AR, PR, GR) are derived from rather subtle but localized structural differences between steroids.
Our results indicate that the activities of PWMs for PR, AR and GR are significantly correlated with survival times of breast cancer patients.
In contrast, as described above, the inferred AC scores of the PWMs for PR, AR, and GR are negatively correlated with patient survival.
Interestingly, we find that ER, PR, AR and GR are positively correlated with patient survival at the expression level, with the Spearman correlation coefficients 0.45 (Q = 0.0035), 0.34 (Q = 0.053), 0.33 (Q = 0.059) and 0.04 (Q = 0.98), respectively.
Since the variations observed among the set of randomized graphs GR are not significant (data not shown), these plots are valid for the set of randomized graphs GR.
Unfortunately, the therapeutic anti-inflammatory actions of GR are concomitant with a host of undesirable side effects that include skin atrophy, glaucoma, osteoporosis, adipogenesis, insulin resistance, and hypertension9.
These results indicate that other factors, in addition to sequence-specific κBRE binding by GR, are required to explain dexamethasone-dependent repression of NF-κB target genes.
The primary roles of these carbon allotropes (C60, CNT, and GR) are found to be quite similar in terms of structure photoactivity correlation analysis.
Finally, simple approximate expressions for the entropy of gray radiation (GR) are presented, as the exclusive use of numerical integration is laborious.
Hybrid aluminum metal matrix composites reinforced with silicon carbide (SiC) and graphite (Gr) are extensively used due to high strength and wear resistance.
Of these, the arginine-rich ones, PR and GR, are highly toxic in a variety of model systems, ranging from human cells, to Drosophila, to even the budding yeast, Saccharomyces cerevisiae.
