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The parameter fitting that Holgado et al. performed suggested that all connections became stronger under Parkinsonian conditions, and they cite several experimental results that support this increase, including the presence of D 2 receptors in the STN [39] and GPe [40, 41] and the enhanced effect of GABA on STN neurons [42, 43] and glutamate on GPe neurons [41, 44] when dopamine is reduced.
There is some evidence to suggest that this decrease of w g g in the Parkinsonian case is more appropriate, based on the effects of increased striatal-pallidal activity on GABA release in the GPe [60, 61].
Hyperdopaminergic HD mice display an accelerated clinical and neuropathological phenotype with early formation of neuropil aggregates that predominate in the GPe [9], which express D2R but not D1R.
Matrix neurons are high in enkephalin, a marker of indirect pathway neurons, and project to the external segment of the globus pallidus (GPe) [2],[7].
malvacearum and Xal GPE PC73.
Strains XaFL07, GPE PC73 and HVO082 all belong to clade MLSA-2.
The Xanthomonas core genome increases to 44% of any Xanthomonas genome once X. albilineans strain GPE PC73 (Xal GPE PC73) is excluded of the analysis.
PR conceived the sequencing project of strains XaS3 and GPE PC73 and revised the manuscript.
Genomic DNA was extracted from X. albilineans strains GPE PC73 and XaFL07-1 as described above.
For comparative analyses, the annotated genome sequences of X. albilineans strain GPE PC73, GenBank accession no.
X. albilineans strain GPE PC73 was isolated from a diseased stalk of sugarcane cv.
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