One can compare survival of two-compartment tumor cell population exposed to DOXO under two scenarios: (1) no cell proliferation, just P-gp exchange and (2) cell proliferation alone assuming equilibrium distribution of P-gp activity.
Reviewer 1: Leonid Hanin, Idaho State University, Department of Mathematics, United States of America This is an important and well-written paper that deals with the efflux P-glycoproteins (P-gp), exchange of P-gp between cells including a mathematical model of this process, and the role of the P-gp transfer in bringing about extragenetic resistance to chemotherapeutic treatment of breast cancer.
2. To put formation of chemotherapeutic drug resistance into a more practical perspective, it would be helpful to mention whether normal breast tissue cells display P-gp based efflux activity and whether P-gp exchange may occur between normal and malignant cells.
You really need to 'do' something with it, such as discussing the guideline recommendations in small group of GPs, exchanging arguments, and discussing pros and cons.
Other factors mediating care included the use of the public versus private health system, the quality of information exchange (GP to specialist and GP to patient), continuity of care between GP and specialist, and the extent of information provision when patients moved between specialist and GP care.
As concerns information exchange between GPs and specialists, Westermann et al. [ 7] reported a lack of information in GP letters (for example, the primary diagnosis or concern for the patient was missing in nearly half of the letters), as well as delayed responses by specialists (39 to 46 days after patient consultation).
Welcome to a typical exchange in GPs: Behind Closed Doors (Channel 5, 8pm).
Decisions about referrals to hospital care are not based on CPI exchanges during GP consultations.
The results presented here pertain specifically to what GPs said about information exchange, communication and services.
Knowledge exchange with GPs and peers provides a valuable teaching and learning opportunity that develops interprofessional teamwork.
