Although high expression of IL-6 has been proposed to contribute to bone loss in GIOP, the clinical data is conflicting and it appears that the up-regulation of soluble IL-6 receptor (sIL-6Rα and its ratio to soluble gp130 co-receptor governs the effects on bone during inflammation [50], [51], [52], [53].
"They're saying, 'We can't apply the rules that govern the effect of terminating J-51 benefits because J-51 benefits are terminated,' " he said.
The main concepts governing the effect of pressure on materials synthesis is by the combination of high pressure and high temperature which are described with apt examples.
However, accounting for the action of mechanical stresses in this approach is associated with considerable difficulties, since it requires knowledge of regularities governing the effect of these stresses on the energy barrier height [12].
In this study, we systematically mine through a huge database on skin permeabilizing effect of over 4000 binary formulations generated by high throughput screening and extract general principles that govern the effect of binary combinations of chemicals on skin's barrier properties.
The amount of heterogeneity in sexual contact rates is an essential parameter governing the effect of MC for given equilibrium HIV prevalences.
Speaking in Athens last November, the Italian philosopher Giorgio Agamben discussed an epochal transformation in the idea of government, "whereby the traditional hierarchical relation between causes and effects is inverted, so that, instead of governing the causes – a difficult and expensive undertaking – governments simply try to govern the effects".
Using a feed-forward network of orientation tuned neurons with adapting synapses (Fig 4B), our model explains both the repulsive shift observed in the orientation tuning curve after adaptation, as well as the separate time scales which govern the effects on the two flanks (Fig 4C and D).
Some studies have shown changes in transcript levels of key regulatory members of the Gh/Igf1 pathway [14], [15] and have even begun to connect the hormonal mechanisms governing the effects of CR in mammals to the cellular mechanisms found in other model organisms, e.g. the TOR pathway [16], [17].
The interactions that govern the effects of cytokines are poorly understood in general, and even less-well understood in the context of TBI.
