This observation implies that drug treatment in laminopathies that show defective lamin A processing must take into account several factors, including levels and functionality of mature lamin A. Our data demonstrate that molecules that govern large scale chromatin arrangement, such as LAP2 alpha and SIRT1, are affected in MADA.
The other main result stands in the consistency with respect to the asymptotics reached at small and large time scales in low Froude regimes, which governs large-scale oceanic circulation.
We present a spectral element model to solve the hydrostatic primitive equations governing large-scale geophysical flows.
Despite the significant progress in uncovering the molecular details underlying cytoskeletal dynamics, the principles governing large-scale coordination and polarization of the cytoskeleton are still not well-understood.
Since heat transport is mathematically an integral process that is dependent on large length scale fluid flow variations and even the variance of the aperture is governed by the large scale, it is not surprising that varying the Hurst coefficient has little impact on the distribution of thermal performance.
Most computational principles in the Cloud are governed by the notion that large scale distributed systems see failures so frequently that failover and recoverability must be an integral part of the software design.
The Symposium has a promising thematic: "How does a digital Earth govern itself?", taking on the large scale design of not-yet-defined and seriously emergent digital entities and geographies that regulate, distribute, manipulate and shift the spaces of political, cultural, social and economic organization.
Comparison of the statistical properties of the CMB with the predictions of parametric models has revolutionized our understanding of the basic physics that governs the large-scale properties of our Universe.
The new discoveries show that the gravitational waves predicted by Einstein's theory of relativity, which governs very large-scale phenomena, are also quantum phenomena.
The large scale chain motions which govern the length and width recovery appear to occur independently, but the small scale motions appear to take place consecutively.
The comparison revealed that the plastic part of the J-integral is the parameter governing the short crack growth rate in large scale yielding conditions.
