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Not included in this ribozyme review, but of interest to the bioinorganic chemistry of RNA, are the fascinating cases of "functional" metal-ion interactions in RNAs that do not perform chemical reactions but whose metal-dependent structure governs gene expression.
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It is also possible that in the co-culture situation production of secreted factors from the ligand-expressing cell may synergize with Notch ligand activation to govern gene expression, which may at least in part explain the difference between the "co-culture" and "immobilized" Notch signatures.
Why it matters: Researchers can finally study the genetic differences governing gene expression.
A group of regulatory events, referred to as epigenetics, govern gene expression without affecting the underlying DNA sequence.
Multi-protein assemblages known as enhanceosomes govern gene expression by local committee thus dictating regional transcription factor function.
After undergraduate studies in physics, he became fascinated by the processes that govern gene expression, particularly in understanding how gene expression is regulated by information encoded in the genome.
Such events also span multiple time domains from the fast molecular reactions governing gene expression to the slower cell cycle and division.
HHMI Investigator and Professor Barbara Meyer was honored with the 2018 Thomas Hunt Morgan Medal from the Genetics Society of America GSAA), which recognizes Dr. Meyer's lifetime achievement in the field of genetics and her groundbreaking work on chromosome behaviors that govern gene expression, development, and heredity.
These findings illustrate how the Tor and cAMP-PKA signaling pathways respond to nutrient signals to govern gene expression required for cell growth via two parallel routes, and they have broad implication for our understanding of analogous regulatory networks in normal and neoplastic mammalian cells.
The regulatory networks governing gene expression can diverge significantly among different bacteria.
Epistasis (synergistic interaction) among SNPs governing gene expression is likely to arise within transcriptional networks.
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