Sentence examples for governing specificity from inspiring English sources

The isolation of two different Rep regions involved in ITR specificity was consistent with the discovery of two independent elements governing specificity within the ITR.

However, the actual mechanisms governing specificity, in terms of which RNAs are selectively packaged into vesicles, remain unknown.

The length of the linker between the different RRM domains is known to govern specificity of RNA-binding, since a single RRM domain can bind from only four to eight nucleotides [ 9].

Many TF-binding preferences, however, are unknown or poorly characterized, in part due to the difficulty associated with determining their specificity experimentally, and an incomplete understanding of the mechanisms governing sequence specificity.

Here, we present an evaluation of how well a panel of inference algorithms can predict TF DNA-binding specificity data derived from PBM experiments, in an effort to gain deeper insight into the mechanisms governing the specificity of protein DNA interactions, and also to identify a means to project binding preferences to proteins without known binding preferences.

Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor.

The mechanism governing donor specificity and the evolutional trajectory of these unique enzymes have been widely discussed but are still unclear1,5,6,8,9,10,11,12.

Characterization of such host membrane factors will provide useful information regarding molecular mechanisms governing membrane specificity for viral RNA replication.

As Gγ2, Gγ3, Gγ12, and Gγ13 are commonly incorporated with the geranylgeranyl lipid motif, factors other than Gγ prenylation and PLC activity may also be important for governing the specificity of Gβγ-mediated PKD activation.

Recently, we developed a method aimed at predicting interaction sites using experimental interaction data and applied it to the MADS domain protein family [ 53] followed by experimental testing of sites governing interaction specificity [ 54].

Given that the degree of substrate specificity exhibited by an RS is functionally coupled to the accuracy of protein translation, the RS is restrained by tremendous selective pressure; therefore, integration of structural approaches with directed evolution of RSs can expand upon our understanding of the evolutionary tenets governing substrate specificity and selection.