Concluding, it can be stated that the carrier engineering, or generally carrier properties, govern downstream processing, whereas the API engineering and API properties govern the aerosolisation performance and thereby significantly affect the dose delivery to the lungs.
In both of these systems, metal-dependent conformational changes in RNA structure govern downstream expression of metal-uptake genes.
These observations suggest that autophagy governs the downstream pro-apoptotic effectors to execute growth arrest in BCa cells.
In industrial settings, the titer often governs the downstream process costs such as the cost of separating the desired chemical from the byproducts.
The protein integrates diverse signals associated with DNA damage and uncontrolled proliferation to govern adaptive downstream responses such as increased DNA repair, arrested cell cycle, and apoptosis (Vousden and Lane, 2007).
That these effects occur at a drug dose that failed to inhibit cell proliferation suggests that processes governing tumor metastasis downstream of PI3K/mTOR may be independent of those driving proliferation.
Given the pro-tumorigenic cellular processes governed by β1-integrin signalling and given the effect of JAM-A expression on β1-integrin protein expression, it was logical to hypothesize that JAM-A may directly regulate downstream β1-integrin-mediated processes.
While hormonal and neuronal influences have been demonstrated for pigment distribution, cell morphology, proliferation and survival of differentiated chromatophores, less is known about the downstream effectors governing these processes.
This is in agreement with earlier observations that CRZ1 only modestly governs drug resistance downstream to calcineurin and probably has no major role in some of other effectors functions.
The pathways that govern ILC differentiation downstream of the CLP have recently begun to be unraveled.
