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Our results demonstrate that inherent sequence characteristics govern variation in coverage and suggest that some of this variation, like GC content, should be controlled for in, for example, RNA-Seq and detection of copy number variation.
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Similarly, the chemical properties of drugs might govern variations in the nature of seemingly identical mechanisms of drug resistance.
The most important finding of this study was the discovery in Arabidopsis of two major loci governing variation in partial resistance to Pst, in the Bay-0×Shahdara RIL population.
Common to several of the factors implicated in governing variation in both neutral substitution rate and substitution rate asymmetries is a certain degree of conservation over time.
The lack of control over genetic background and environmental conditions, including previous exposures and olfactory learning, make it challenging to study the complex genetic architecture that governs variation in olfactory perception in human populations.
In bacteria [ 18, 25, 26] and nematodes [ 20], the global GC-content is the major factor governing variations in amino acid composition of their genes.
We propose vascular density and blood flow within a tumor as a primary evolutionary force governing variations in the phenotypic properties of cancer cells thus providing a unifying ecological framework for understanding intratumoral heterogeneity.
Different mutational processes govern allelic variation at SSR and SNP loci, with mutation rates of SNP being several orders of magnitude lower than those of SSR.
The next great challenge of pharmacogenetics is to pin down the cellular location and effect of these variant proteins on the pathways and networks that govern individual variation in responses to drugs and other exogenous chemicals.
This is likely to reflect some combination of the model missing processes that might affect crown radius (e.g. soil type); and measurement error for crown radius, both of which are included implicitly in the parameters that govern unexplained variation.
An important objective of evolutionary biology is to understand the processes that govern phenotypic variation in natural populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com