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Recent understanding of the molecular pathways that govern the progression of primary tumors to metastatic disease, points to the EMT as a central stage.
Therefore, there must be additional factors other than cell cycle regulators that govern the progression of these neoplastic lesions.
Further studies are now needed to explore this hypothesis and it may be that several different factors govern the progression of carotid IMT in SLE.
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The interactions between the subnetwork hubs are putative regulatory interactions governing the progression of the cell cycle.
Clarification of these issues would be a significant advance in the understanding of the cellular pathways governing the progression of muscle stem cell lineage.
Therefore, improvement in the therapy of recurrent or metastatic HCC now depends on improving our understanding of the complex molecular mechanisms governing the progression and aggressiveness of the disease, and looking for valuable prognostic markers and therapeutic targets.
While little is known about the biology of breast cancer metastases themselves, the steps governing the progression from primary breast tumor to seeding of distant metastatic lesions has been a focal point of intense investigation (for review see refs. [ 16, 17]).
These results provided new insights into understanding the potential mechanisms that govern the HCC progression.
These results provided new insights for understanding the potential mechanisms that govern the PDAC progression.
We found that fruit flies make frequent transitions between body cleaning and leg rubbing and that these oscillations can be explained by the same hierarchical rules as those that govern the sequential progression of the behavior.
The CDKs are the key regulatory elements governing the ordered progression of the mammalian cell cycle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com