This well established inhomogeneity of biological networks highlights the role of hubs, a small minority of strongly connected proteins [2], [3], which govern a networks integrity.
On one hand, if a few nodes can govern a regulatory network modeling a disease, a gene perturbation/gene silencing approach can be a good strategy for treatment.
We show that the previously reported top-down approach is inadequate to infer the hierarchy governing a regulatory network because feedback bridges different hierarchical layers, and the top-down approach disregards the presence of intermodular genes shaping the integration layer.
Analysing markets as organisations governed by a network of relational contracts that establish rules for market participants increases our understanding of exchange processes.
Looking far into the future, Tocqueville feared that as individuals increasingly turned to the nanny state to regulate the most minute aspects of social life, personal interactions might be governed by "a network of small, complicated, painstaking, uniform rules".
Damage in different directions is governed by a network evolution concept which describes the changes in the inter-aggregate distribution of polymer chains.
The proposed architecture is similar to the well known subsumption architecture in that the movements are governed by a network of various reflexion patterns.
Its fluorescent emission in the solid state can be fine-tuned rapidly and reversibly over a wide (∼100 nm) range of wavelengths as a result of stimuli-responsive aggregation and de-aggregation processes that are governed by a network of supramolecular equilibria.
As in FGFR1 3 kinases, FGFR4K autoinhibition is principally governed by a network of inhibitory hydrogen bonds at the kinase hinge region termed the molecular brake.
However, even the basic operational principles governing a brain's interconnected network of cells have remained painfully elusive.
