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Forth, assuming that gout is a risk factor for CAD, we expected to observe significantly more CAD patients in the gout sample than in gout-free controls.
Nine of the 42 possible haplotypes could be observed with only two (AATT and GGCC) having frequencies >0.05 in cases and controls of the gout sample.
However, given the likely weak effect, confirmation of this will require larger gout sample sets.
No significant association of serum urate with alcohol consumption was observed in gout sample sets of both ancestries (Table 3).
Eurogout is a European Gout Genetics Consortium, established under the aegis of the European Crystal Network in 2010 for the recruitment of a very large, well-ascertained gout sample set for use in genome-wide genetic studies.
This study aimed to determine the frequency of tomato consumption as a self-reported trigger of gout flares in a large gout sample set from New Zealand (including Māori and Pacific Island participants).
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RA and gout samples were matched in terms of macrophage numbers and IL-6 and IL-8 expression.
Interestingly, our histological observation also revealed that the expressions of SHIP-1 in acute gout samples were fewer than those in OA samples.
We undertook a similar analysis in men in the combined Māori and Pacific Island non-gout sample set (Additional file 1: Table S5).
This included an overlap of 220 individuals from gout case sample in CAD/MI case sample, 337 individuals from gout control sample in CAD/MI case sample, 108 individuals from gout case sample in CAD/MI control sample, and 217 individuals from gout control sample in CAD/MI control sample, respectively.
Use of larger gout case sample sets should enable this to be done.
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