Panitumumab appears to have a good tolerability profile, with no maximum tolerated dose yet defined.
Gabapentin has a good tolerability profile [154].
It has analgesic properties and a good tolerability profile in a variety of painful conditions.
First-choice drugs for prophylaxis are beta-blockers, particularly atenolol, metoprolol and bisoprolol because of their good tolerability profile [401].
They include telcagepant (formerly MK-0974) whosefficacycy has been shown in a study involving 500 migraine patients with good tolerability profile.
Although paroxetine, escitalopram, fluvoxamine and sertraline are sometimes used for migraine prophylaxis due to their good tolerability profile, available data are limited and contrasting [139 143].
Lanthanum carbonate (LC) is a noncalcium-containing phosphate binder of proven utility in treating hyperphosphatemia in dialysis patients, and displays a good tolerability profile.
Given the good tolerability profile when performed every 3 monthly, GONBs can play a useful role in the management of CCH, allowing frequent periods of relief from an otherwise highly disabling disorder.
Given the recent evidence of efficacy of lisinopril and candesartan in migraine prophylaxis, their use can be considered because of the good tolerability profile especially in the presence of hypertension.
Clinically meaningful antitumor activity, symptom relief, and a good tolerability profile have been shown in phase II trials of gefitinib monotherapy in patients with recurrent non-small cell lung cancer.
A phase I study in healthy volunteers – the first study in the PROLONG-7FP program – confirmed that rVIIa-FP has a good tolerability profile in doses of up to 1,000 μg/kg and has demonstrated enhanced pharmacodynamic activity relative to rFVIIa.
