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Avoidance of estrogen peaks and withdrawal could contribute to good tolerability of this contraceptive in migraineurs.
High safety and good tolerability of a drug are critical for its OTC authorisation [2].
In vivo studies showed good tolerability of CdSe QDs with ZnS shell and GSH capping.
Our study has clearly demonstrated the benefits, safety, and good tolerability of Kuzik in the prophylaxis of migraine without aura and the use of this medication should be taken in consideration as a good practice in this setting of patients.
This was even the case when the plant combination was administered in a tenfold higher human equivalent dosage - a finding consistent with the very good tolerability of CLR in the pilot study.
Single-agent studies have reported the good tolerability of rituximab.
The good tolerability of irinotecan in this heavily pretreated group of patients was, however, remarkable.
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Given the inexpensive nature and good tolerability profile of HCQ that has been established over decades of clinical experience, our findings point to a potential novel role for this old drug as a cost-effective selective HR slowing agent that may be readily tested and translatable to resource-limited settings worldwide to treat the global epidemic of cardiovascular disease.
Like other agents in the DPP-4 inhibitor class, it offers good tolerability, lack of severe hypoglycemia, and weight neutrality as major advantages.
Finally, if we consider the good tolerability profile of berberine, especially if formulated in such a manner as to bypass the problem arising from the presence of P-gp in the enterocytes, 13, 22 it may be considered a valid opportunity to obtain the best lipidic control in statin-intolerant patients, in particular when they are also affected by diabetes.
Frovatriptan was chosen mainly because of the rapid speed of action (71% of patients), good tolerability (42% of patients), and reduction in pain severity (33%).
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