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My father thanks Nick for the concern in his voice but assures him that his cancer is not an uncomfortable topic because he's "got a good remission going".
In spite of speculation and anecdotal evidence to the contrary, this is the second report from our group showing that adolescent bipolar patients, early in the course of severe illness, can be maintained in very good remission on monotherapy [ 22].
In particular, good remission rates were demonstrated by Jury et al (68% of 25 children treated with a median of 24 exposures) and by Clayton et al (40% of 50 children with severe AD treated with more than ten exposures) in their studies.
7 the tumour was so large that good remission of the embolized part had to be assessed as overall stable disease and repetition seemed to be promising, and in the only patient with progression a desperate attempt was made by repetition.
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Lithium was continued with good remissions (though some recurrent affective episodes and hospitalizations).
After the DLI phase, the response rate was 68%, but a significant upgrade of response was observed: 3 stringent complete remissions, 2 complete remissions, 5 very good partial remissions, 1 partial remission, 4 with stable disease, and 1 with progressive disease.
Table 5 Predictors of good lithium response Positive family history for bipolar disorder Previous remission with lithium Classical: euphoric manic episodes Full remission between episodes Good adherence .
Among the 38 remaining patients, the result of the procedure was complete resection (CR) in 23, either with a microscopic residue (n=18) or without (n=5), very good partial remission (VGPR) in 14 and partial remission (simple biopsy) in one.
The overall median survival from presentation is 14 years, being the same for patients in CR and PR with minimal residual abnormality (good partial remission, GPR), and being better for those for whom remission was achieved than those for whom it was not.
As reported under the 'Results' section and summarized in Tables 4 and 5, the adoption of these therapeutic measures closely reflecting those described in recent reports [[7], [28]] allowed us to yield a good response (remission + improvement) in 73 patients (70.2%) at a mean follow-up of 24 months.
He borrows some unofficial medical terminology from the world of myeloma treatment and says it could be described as a VGPR -- a Very Good Partial Remission.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com