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We found that many searches brought back very few good quality studies: we needed more large-scale randomised trials and well conducted systematic reviews to tell us about the effectiveness and safety of treatments.
In order to minimise this error, you have to amalgamate all the good quality studies to increase the population base of your work and bring in a variety of settings, thus ironing out any discrepancies.
There are anecdotal reports of improvement in muscle symptoms with administration of an over-the-counter supplement, coenzyme Q10, but benefits are not well documented via good quality studies.
Therefore the report advocates for conducting good quality studies, as described, going forward.
A rigorous search strategy and distinct inclusion and exclusion criteria were employed which yielded a diverse range of relevant good quality studies.
We were unable to get the heart rates of the pigs low enough to permit good quality studies on a 16-slice CT scanner.
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The risk/benefit ratio of bisphosphonates has been documented in multiple good-quality studies.
However, good-quality studies on NPS in this under-researched population are lacking.
For good-quality studies (five studies) comparing CT and US in the same population, CT was more sensitive (88.4%% vs 76%%) and a little bit more specific (90.4%% vs 89.4%%) than US [23].
A 2007 Cochrane review did not find any good-quality studies upon which to base recommendations and they are not believed to have an effect on airway edema or spasm.
We reviewed eleven studies and regarded only five of these as good-quality studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com