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On the whole, the high consistency between the simulated fluxes and the calculated 13C fluxes validated the good prediction performance of iRY1243.
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The authors evaluated this method utilizing iEEG data from eight patients and a total of 1400 h, which include 172 seizures and reported a good prediction performance for 40% of the patients.
Indeed, no team achieved a good prediction performance for network 2. In case of genes with low wild type expression, over-expression instead of knockout experiments should be performed.
The algorithm shows good prediction performance (an improvement of up to 10% in terms of MAE compared to regression-based methods), but training a personalized function for each user makes it difficult to be implemented in large-scale social networks.
Network architecture gave good prediction performance with low values of mean absolute percentage error and high coefficient of determination.
Finally, 'feature selection' was conducted to investigate whether we can still achieve good prediction performance with only a subset of features.
From Table 2, we can see that our model gives good prediction performance with an average sensitivity value of 85.74%, precision value of 93.84%, MCC value of 82.03%, and AUC value of 95.28%.
From Table 2, we can see that our model gives good prediction performance with an average sensitivity value of 84.08%, specificity value of 85.53%, PPV value of 85.47%, NPV value of 84.15%, F-score value of 84.77%, MCC value of 74.22%, and AUC value of 0.9232.
From Table 3, we can see that our model gives good prediction performance with an average sensitivity value of 85.74%, specificity value of 94.37%, PPV value of 93.84%, NPV value of 86.89%, F-score value of 89.61%, MCC value of 82.03%, and AUC value of 95.28%.
CBEP achieves good prediction performance with the mean AUC scores (AUCs) of 0.721 and 0.703 on two benchmark datasets (bound and unbound) using the leave-one-out cross-validation (LOOCV).
A high Pr value would indicate good prediction performance and that the response was predictable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com