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"That the actuality is also better and more valuable than the good potency is evident from the following argument.
These compounds exhibit good potency for MMP-2 and MMP-9 without inhibiting MMP-1.
Most potent compounds showed good potency in both enzymatic and functional human whole blood assay.
They show good potency for enzyme inhibition and excellent functional activity.
The lead in the series, 3g, exhibited high affinity and good potency.
Compound 1 shows a promising ADME Tox profile and good potency.
When incorporated with the phenyl ring on sulfonamide moiety, aminopyrimidine analogs showed good potency on PI3Kβ and selectivity over PI3Kα.
Most of the compounds exhibited good potency against EGFRwt and some showed moderate to excellent potency against EGFRT790M/L858R mutant.
Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM).
Pegylation of a potent analog has provided compounds with good potency and good in vivo pharmacokinetic properties.
The designed molecule showed good potency, binding interactions and scores in docking and ONIOM single point energy study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com