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These derivatives have been obtained with good overall yields.
These compounds were synthesized in good overall yields in seven steps starting from 2-bromoanisole.
The synthesis of the analogs of both series is multistep and proceeds in good overall yields.
The product of this reaction was treated with KOH to give compounds 4 in satisfactory to very good overall yields.
Moreover, the synthetic procedures described herein, allows rapid entries to synthetically challenging medium-sized heterocyclic systems with good overall yields.
This strategy offered a very straightforward and efficient method for access to the designed amphiphiles in good overall yields.
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Lewis acid catalyzed glycosidation gave the selectively protected disaccharide ethylthioglycoside in good overall yield.
A series of 15 novel bidentate ligands was prepared in 6 11 steps in good overall yield (24 43%).
Addition of an amine and TMSCN similarly led after Strecker reaction/lactamization to α-cyano-piperidinones in good overall yield.
Nine-step conversion of methyl hydroxypivalate 6 provided the desired A-ring enyne synthon (13a,b) in good overall yield.
Solid-phase Evans' asymmetric alkylation on 23-derived N-acylimide resin and following lithium hydroperoxide-mediated chemoselective hydrolysis afforded the corresponding α-branched carboxylic acids in desired high stereoselectivities (up to 97% ee) and moderate to good overall yield (up to 70%, for 3 steps), which were comparable to those of the conventional solution-phase methods.
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