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This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.
Compound 6c was further found to be effective in a murine model of BCG infection, providing a good lead for subsequent optimization.
Therefore, the selective 5-HT7R antagonist 28 can be considered as a good lead for discovery of novel 5-HT7R astantidepressantsidepressantidepressants
Overall, these results suggest that the brassilexin scaffold is a good lead for further development of paldoxins against L. maculans, as it inhibits competitively BOLm without apparent induction.
Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.
It was shown that microseismic monitoring along with the coupled geomechanics, fluid flow models and statistical analysis of the microseismic data can provide a good lead for prediction of potential fault reactivation and induced seismicity generation in association with oil and gas production, EOR and EGS fluid injection and waste disposal operations.
Similar(46)
The novel active chemical entities reported here should be good leads for further development of purine-based anticancer drugs targeting Src tyrosine kinase.
Compounds 1 and 2 showed activity for all four strains suggesting that these compounds may be good leads for the development of novel antimalarial drugs.
Blood and semen samples were collected at the scene of the crime in 1991, but DNA testing at the time didn't provide any good leads for the police.
We therefore speculate that in particular the highly expressed unconventional RBPs may give good leads for future experiments as they have the potential to control many RNA targets [28].
ChIP-PED acts primarily as a guide to highlight biological contexts that would be good leads for experimental investigation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com