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Major experimental issues that need to be addressed: There is still lingering concern about the role of the C-terminal domain in the catalytic cycle of MCAK. 1) The authors show that the MCAK motor domain binds to microtubules with good binding affinity and that the modified (Cys containing) C-terminal peptide does not affect the binding affinity under reducing conditions.
The complexes show good binding affinity towards CT-DNA.
The docking results demonstrated that piperine has good binding affinity towards CD4 and CD8 receptors.
Methotrexate-alpha-arginine and fluoresceinated have also exhibited good binding affinity − 38.85 and − 37.27 respectively.
These bifunctional ligands showed very good binding affinity towards the both μ and δ opioid receptors.
NBI 30545 (18n) was found to have good binding affinity and potent antagonistic activity at the human CRF1 receptor.
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As suggested by computational studies, all compounds bind with H+/K+ ATPase having good binding affinities.
Binding affinity results of the prepared compounds revealed good binding affinities at both melatonin receptor subtypes.
Berberine and palmatine had good binding affinities.
Docking studies of diverse reported structures with modeled protein exhibited good binding affinities.
Several compounds such as 20c (Ki=10 nM) exhibited good binding affinities at the CRF1 receptor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com