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The Food and Drug Administration, which licences medicines in the US, believes the Ebola drug trials should be set up in west Africa on the "gold standard" model designed to provide a conclusive answer as to whether they have an effect.
Both surgically induced and naturally occurring canine models of OA have been extensively studied as this species is thought by some to be the closest to a gold standard model.
Sterile protection in this gold standard model is considered to depend on a combination of the antibody responses induced against CSP, leading to sporozoite inactivation and inhibition of hepatocyte invasion, and on the cellular responses induced against CSP, leading to the destruction of infected hepatocytes.
CLP is considered the gold standard model for experimental sepsis [ 25].
Arguably, macaques are considered the "gold standard" model(s) of arenaviruses and generally recapitulate human disease.
The gold standard model of latently infected cells is resting CD4+ T cells from HIV-infected patients on suppressive cART.
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Measurements of PE wear postoperatively and at final follow-up (after mean 6 years) on plain radiographs of 12 patients after cementless THA were evaluated with PolyWare software and the results were compared with those from RSA as the gold standard (Model-based RSA using elementary geometrical shape models; EGS-RSA).
Actually, no gold standard modeling approach exists but it should be driven by the type of effect to be estimated.
This method has been validated for global parameters such as LV mass, end-diastolic volume, end-systolic volume, stroke volume and ejection fraction using global gold standard models [ 133].
We here used the gold-standard model of LID and PD, the L-dopa-treated MPTP-lesioned macaque model.
Consequently, no gold-standard model for determining DED severity exists.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com