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8 Measurement of population salt consumption is fundamental for planning and monitoring salt reduction policies and the gold standard method is based on a 24 h urine collection from a random community sample.
The "gold standard" method is a prospective cohort study; however, its disadvantages are it is expensive, difficult to maintain retention rate, lack of representative sampling, and the Hawthorne effect which affects a subject's behavior and may produce a bias conclusion [ 20, 21].
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IR, as measured by the gold standard method, was also unaffected (see the next section).
The gold standard method was the hyperinsulinemic-euglycemic clamp (glucose clamp) technique, originally developed by DeFronzo [ 4].
The overall agreement between MEBGEN RASKET KIT and the gold standard methods was 96.7%.
Similar "gold standard" methods are available in transcriptomics (DNA microarray), proteomics (multidimensional separation coupling with mass spectrometry) and metabolomics (microseparation coupled with mass spectrometry and nuclear magnetic resonance).
For HCII accuracy, we did find that the use of gold standard methods was contributed to heterogeneity (dOR = 2.87 [95% CI: 1.31 6.29], P = 0.009, comparison between histology and cytology, cytology = reference group).
Since no "gold-standard" method is available to continuously, reliably, and effectively monitor the effects of sedatives and anesthetics, such a method is greatly needed.
To evaluate DNA methylation, the gold-standard method is based on sodium bisulfite conversion [ 14], in which unmethylated cytosines are converted into uracils.
No 'gold standard' method was used to validate our delirium diagnoses; however, both delirium measures used have been externally validated and are widely employed.
For many studies involving biomarker assay, an IDE is not required because the data from biomarker assay studies can be compared to a gold standard method which is used for patient care.
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