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Theoretically, a repeat association with precisely the same variant in an independent sample is the gold standard for replication, but testing additional variants is commonplace in replication studies.
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We question whether it is necessary or sufficient to regard replication as the gold standard for defining a true susceptibility variant.
Replication has become the gold standard for assessing statistical results from genome-wide association studies.
We also wish to raise the question whether it is sufficient or necessary to treat replication as the ultimate and gold standard for defining true variants.
Intuitively, replication ought to be an effective gold standard for substantiating gene-disease associations because it serves as independent statistical confirmation.
The accepted gold standard for demonstrating associations in omic research settings, such as genome wide association studies, is the independent replication of preliminary findings [ 1].
Bell Labs was the gold standard for innovation.
The gold standard for Los Angeles coffee.
"It's the gold standard for treatment.
You are the gold standard for friendship.
It's the current gold standard for YouTube footage.
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