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The former study included limited number of patients in the more severe subgroups, with 21 GOLD stage 0, 9 GOLD stage I, 10 GOLD stage II and only 3 GOLD stage III patients.
In the present study the SGRQ Total score ranged from 23 in GOLD stage I to 56 in GOLD stage IV (according to BTS 23 47).
Of these subjects, 62.5% were classified as GOLD stage I, and 37.5% were GOLD stage II.
A total of 15 participants with GOLD Stage II COPD and one participant with GOLD Stage III COPD were recruited to the trial with 100% compliance to the both interventions.
The use of Chinese traditional medicine was increased as the disease progressing: 8.3% (1/12) in GOLD stage II patients, 19.1% (4/21) in GOLD stage III patients and 20.0% (2/10) in GOLD stage IV patents.
Currently, there are more participants in the healthy group and in GOLD stage 2, while participants in GOLD stage 4 are being recruited.
To better understand the pathobiology of disease severity in COPD, we searched for genes differentially expressed in lung tissue using microarrays between mild (GOLD Stage I) and moderate (GOLD Stage II) COPD patients, stratifying them by FEV1.
The average gene expression for cases with moderate COPD (GOLD Stage II) divided by the arithmetic average of expression in cases with mild COPD (GOLD Stage I) was calculated as the fold change.
These 46 genes were 67% accurate in classifying mild (GOLD stage I) and moderate (GOLD stage II) COPD using LOOCV with diagonal linear discriminate algorithm in the training samples.
In the Swiss cohort 63% was classified as GOLD stage II, 27% as GOLD stage III, and 11% as GOLD stage IV.
In COPD patients it increased by 16% for GOLD stage 1, by 48% in GOLD stage 2 and by 56% in GOLD stage 3.
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