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Now, sometimes people would go groups for a long time at the end of class to post a video.
Follow your teammates wherever they go, groups are harder to kill.
Classification of genes by Gene Ontology (GO) groups and statistical testing of over-representation among GO groups was done separately for genes with increased and reduced expression.
We identified GO groups whose gene expression patterns were significantly different among treatments.
This single ranking gives an average PPV of 4.7% averaged across GO groups.
However, our analysis additionally identifies several novel GO groups related to nervous system function (Table 1).
Among them, 58 clusters were derived from literature-based custom GO groups.
All analysis used only the GO groups with 20 1000 genes, except where specified otherwise (e.g., Data S1 Section 4).
Highly-ranked GO groups are the "most multifunctional" – the genes they contain tend to be highly multifunctional.
The top 100 network for AUP evaluation was constructed by adding connections between genes with many overlapping GO groups.
Then, the program iterates over all gene ontology groups containing a minimum of two known genes in the expression data matrix; this corresponds to 2,708 GO groups (including our virtual literature-derived categories) for the malaria dataset, 2,210 GO groups for the yeast dataset, and 4,428 GO groups for the human tissue dataset.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com