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GO cluster were found using GO term finder option in www.candidagenome.org.org
Therefore, only significant expressional changes when comparing HCID vs. HCIS will be discussed based on genes assigned to the categories "inflammation", "apoptosis" and "growth" found in GO cluster analysis of biological processes (Table 4).
Step 1. Constructing the co-expression networks for each GO cluster We build the networks for each GO cluster.
DAVID joined these into a single GO cluster with an enrichment score of 16.8.
The GO cluster analysis was used and any clusters with enrichment scores below 1.0 were discarded.
High translational activity possessed by HGMEC was reflected by the overexpression of "translation and energy metabolism" GO cluster.
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Although a negative going significant cluster appeared for both the slowed down sequence and the strong AM stimulus condition around 100 110 ms, the earlier positive going cluster existed only in the strong AM stimulus condition (Diff(AM)).
Multiple GO clusters were not assigned to one of these categories due to lack of coherence.
GO clusters with an enrichment score greater than 1.3 were considered significant [35], [36].
In the cortex, 81 GO clusters were formed but only 15 of them showed an enrichment score greater than 1.3.
The genes associated to specific GO clusters were then summarized in six defined categories (Tables S1 and Table S2).
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