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Similar holds for GO molecular functions (GO-MFs) and GO cellular component annotations (GO-CC), as presented in the middle and right panels of Fig. 3).
We construct GO terms from GO biological processes, GO cellular components and GO molecular functions using the org.Hs.eg.db and GO.db R packages.
The results of the overrepresentation test were statistically significant only in the AIS group of upregulated genes for the categories of GO molecular function and GO cellular component.
Additional file 2 shows the GO plots and box plots corresponding to the GO cellular component category.
Annotation data sets used were the complete GO biological process, GO cellular component and GO molecular function.
> GO categories were assigned to all targets, including 514 known targets and 249 new candidates, according to three ontologies in GO: cellular component, molecular function, and biological process.
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Unfortunately, it was also "sponsored" like a pro snowboarder — in this case by Boost Mobile, a pay-as-you-go cellular provider.
GO-cellular component annotations for 7,439 interactions were inconsistent; i.e. participating proteins were reported in different compartments, and have thus been discarded from the analysis.
The network displays non-random distribution and local clustering of proteins with the same subcellular localizations, approximated by GO-cellular compartment.
Putative assignments were made from the GO subsets [GO: Molecular function], [GO: Biological process] and [GO: Cellular component].
In the [GO: cellular process] category the highest hit rates occurred in the child terms [GO: cellular metabolism, cellular macromolecular metabolism] and [GO: cellular protein metabolism].
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