After modeling, 60 rats of the model group were randomly divided into 3 groups, namely BA treatment group, the glutamine treatment control group and the model control group with 20 rats in each group.
During the study period, glutamine and control powder are monitored for stability and microbiological contamination.
It was unbalanced in patients with three or more organ failures and nutrition supplementation between glutamine and control group.
Incidence of positive blood cultures and rate of weight gain were not different in glutamine and control groups.
We hypothesise that plasma amino acid profiles in glutamine and control groups will not differ during the study period.
In the other two subgroups, however, no difference was found in the treatment effect on mortality between the glutamine and control groups (see Additional file 2, Figure 6).
Distribution of optimal and non-optimal neuromotor development and normal and abnormal mental/motor development in glutamine and control groups is examined by logistic regression with adjustments for possible confounding factors as gestational age and birth weight.
In Critical Care recently, we read with great interest the systematic review and meta-analysis by van Zanten and colleagues, who compared enteral glutamine with control in critically ill patients in terms of clinical outcomes [ 1].
Muscle soreness was significantly lower over 96 hours with L-glutamine supplementation (Control, 4.6 ± 2.5 units; Glutamine, 3.6 ± 2.5 units, p = 0.03).
These cocrystal structures reveal a common scheme of inhibitor binding to the PDEs: (i) a hydrophobic clamp formed by highly conserved hydrophobic residues that sandwich the inhibitor in the active site; (ii) hydrogen bonding to an invariant glutamine that controls the orientation of inhibitor binding.
