Sentence examples for globally expressing from inspiring English sources
We interrogated our model of HSAN1 by globally expressing dSpt1 C129W and assessed the abundance of sphingolipids.
We raised larvae globally expressing either wild-type dSpt1 or dSpt1 C129W on diets containing 10 m m or 100 m m alanine.
Alanine fed animals globally expressing dSpt1 C129werere used to confirm the identity of the DSB peaks and homozygous dSpt2/ lace P hypomorphs were used as positive controls to identify endogenous sphingoid bases in the wild-type traces based on their absence in dSpt2/ lace P samples (previously shown to have a sphingolipid content of 2.58% (25)).
As can be seen in the graph (Fig. 3C and D), total sphingoid base abundance is reduced in animals globally expressing dSpt1 comparedmpared with controls, while the content of DSBs is only marginally elevated in the dSpt1 C129W animals grown on normal lab food (with no DSBs found in the wild-type animals), suggesting a dominant-negative effect of this mutation on sphingolipid biosynthesis.
As we have previously described that mES cells globally express signal molecules, the global expression of signal molecules might be a common characteristic of ES cells and sperms.
First, most of the enzymatic genes have specialized expression patterns and they are not globally expressed across mammalian tissues [ 14].
Runx transcription factors are critical regulators of metazoan developmental signaling, and we have shown that the sea urchin Runx gene runt-1, which is globally expressed during early embryogenesis, functions in support of blastula stage cell proliferation and expression of the mitogenic genes pkc1, cyclinD, and several wnts.
These results indicated that hES cells also globally expressed tissue-specific surface proteins.
Therefore, we set out to determine whether mES cells globally expressed tissue-specific cell surface proteins.
In conclusion, we demonstrated that mES cells globally expressed cell surface proteins of diverse functions and tissue specificities.
With these findings, the phenomenon that ES cells globally express genes on the mRNA level seems to be well established.
