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First, most of the enzymatic genes have specialized expression patterns and they are not globally expressed across mammalian tissues [ 14].
Runx transcription factors are critical regulators of metazoan developmental signaling, and we have shown that the sea urchin Runx gene runt-1, which is globally expressed during early embryogenesis, functions in support of blastula stage cell proliferation and expression of the mitogenic genes pkc1, cyclinD, and several wnts.
These results indicated that hES cells also globally expressed tissue-specific surface proteins.
Therefore, we set out to determine whether mES cells globally expressed tissue-specific cell surface proteins.
In conclusion, we demonstrated that mES cells globally expressed cell surface proteins of diverse functions and tissue specificities.
Our results showed that mES cells globally expressed a large repertoire of tissue-specific cell surface proteins.
Similar(33)
As we have previously described that mES cells globally express signal molecules, the global expression of signal molecules might be a common characteristic of ES cells and sperms.
Directors globally express the most concern about regulatory and reputational risks, followed by cybersecurity, and less about activist investors and supply chain risks.
With these findings, the phenomenon that ES cells globally express genes on the mRNA level seems to be well established.
The evidence we present here that ES cells globally express a large diversity of surface signaling molecules in a heterogeneous manner may partially explain these properties.
Cell surface proteins could perform critical functions in ES cells, so determining whether ES cells globally express cell surface proteins would have significant implications for ES cell biology.
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