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Treatments used in RCC showed no effect, such as sunitinib, a multitargeted TKI of VEGF-R (Ki-CA IC50 equivalent to globally established median 1000nM), and pazopanib (10,000 nM equivalent to globally established median).
Now that Temperley is a globally established name (it sells in 35 countries worldwide), it is time to move to the next level.
To sum up, for the balance of power model to turn out stable, it needs to be multipolar and globally established as to withdraw the destabilizing presence of weak or unaligned states from the system.
Humanitarian intervention constitutes a globally established tacit regime, because there is a clear discrepancy between its legal basis and actual application, which invalidates the regime's otherwise provided legal framework.
In the context of the finite volume method no single local refinement criterion has been globally established as optimum for the selection of the control volumes to subdivide, since it is not easy to associate the discretisation error with an easily computable quantity in each control volume.
Despite a lack of a supranational authority, the recognition of the established normative framework for the use of military means in old wars by virtually all states and a voluntary adherence to at least some of its principles indicate a globally established classic regime and provide evidence for the experienced need for a regulative framework in the system.
Similar(43)
Companies internationalise, source and sell globally, and establish factories abroad.
We are witnessing a time in biomedical research when systems can be queried globally to establish the metabolic state of the organism in a single experiment.
Nevertheless, there is an ostensible difference between buying a young talent like Sven Bender from 1860 Munich and poaching an already established, globally coveted superstar from a major title rival.
Various green rating systems are established globally to evaluate the sustainability of construction projects.
Zhang et al. established globally asymptotic stability criteria for a GRN with time-varying discrete and unbounded distributed delays [21].
More suggestions(15)
collectively established
essentially established
globally prescribed
globally stated
universally established
generally established
internationally established
globally achieved
globally tested
globally acknowledged
globally discovered
globally pursued
globally maintained
altogether established
comprehensively established
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com