Suggestions(1)
Exact(2)
If high levels of nuclear Hog1 are capable of globally altering transcription, we would expect spurious activation of Hog1 to be detrimental.
In contrast, the use of tissue-specific miRNA mimics or inhibitors may allow for the tissue-specific regulation of SIRT1 to prevent and treat age-related diseases without globally altering SIRT1 activity.
Similar(58)
With attenuation coefficients globally altered by ±10%, similar global over- or underestimation was observed in both phantom and animal studies.
Effects of (1) misalignments between micro-SPECT and micro-CT through shifts and rotation, (2) globally altered attenuation coefficients and (3) combinations of these were evaluated.
They accounted for 19% of global electricity generation in 2011 which according to the report is "broadly on track to meet a 2C scenario by 2020" for a globally altered climate.
Hence, there is a relationship between global warming, decomposition and respiration in soils and wetlands producing significant climate feedbacks and globally altered biogeochemical cycles.
Among these, Glutamatergic (GLU) and GABAergic related genes were globally altered.
It would be interesting to examine how miRNAs globally alter the transcriptomes in tissues other than the inflorescence.
The functional analysis using gene ontologies also revealed that an over-representation of genes involved in cell communication processes were globally altered.
We then analyzed the chromosome territories of both chromosome 13 and chromosome 7 to query whether chromosome compaction was globally altered in the LMNA mutant cells.
We hypothesized that biological processes that are globally altered across different brain regions believed to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations.
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