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Hence, although limiting glucose decreases global translation, certain transcripts may be translated as a part of specific stress responses.
Since phosphorylation of eIF4E and 4EBP activates global translation, our results indicate that translational regulation, rather than mRNA targeting, controls the locally regulated synaptic proteome.
In our experimental conditions eEF1γ-specific siRNA depletion does not affect global translation levels and in particular it does not significantly alter Vimentin translational level.
Under this condition, the global translation is attenuated.
The system also keeps track of previous translations, and matches new ones against its "global Translation Memory".
Elevating levels of misfolded proteins can elicit growth arrest due to ER stress and decreased global translation.
The working group also recognized the importance of international platforms in supporting data sharing, technology transfer, shared risk assessment methods, and global translation of scientific evidence.
This results in transient attenuation of global translation.
In addition, we did not find any impact of eEF1γ depletion on global translation.
A concern with a global translation arrest is that it is a consequence of dying cells.
Active PERK phosphorylates eIF2α, thereby leading to inhibition of global translation.
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