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Global toxicity affecting other tissues than kidneys remains to be investigated after 161Tb-based therapy, however.
The reason why the relative body weight and survival rate did not correlate well with the severity of renal damage in these high-dose treatment groups remains unknown and might involve other factors referring to global toxicity, which were not investigated in this study.
The observation of Ndk-mediated down-modulation of phagosome maturation cannot be attributed to a global toxicity of the host cell maturation.
Oxaliplatin may represent an intriguing alternative to cisplatin with at least comparable activity, but a more favourable global toxicity profile.
Animal studies documented a decrease in global toxicity and an increase in therapeutic effectiveness of chemotherapy when combined with PHY906.
In the last decade, oxaliplatin (L-OHP), a third-generation platinum derivative, has been found to represent an intriguing alternative to cisplatin, as it shows a comparable activity but a more favourable global toxicity profile (Misset et al, 2000).
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Because of the highly restricted nature of its cellular targets (i.e. B cells), specific BLyS antagonists have an excellent chance of not promoting multiple global toxicities.
Trace gaseous compounds showed marginal impacts to global warming and toxicity categories.
Our results revealed that the functionalised nanoparticules and NP grafted polymer cause a global decrease in toxicity compared to commercial nanoparticule and HASE polymer.
Environmental impacts (global warming, ecosystem toxicity, light-chemical oxidation, acidification and solid waste) are shown in the form of weighted values instead of absolute values to obtain optimal locations for facilities in the supply chain.
The following environmental impacts are considered: abiotic depletion, acidification, eutrophication, freshwater, marine and terrestrial ecotoxicity, human toxicity, global warming, ozone layer depletion, photochemical smog, and land use.
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