Sentence examples for global substitution from inspiring English sources
Global substitution of the amino acids in proteins by fluorinated amino acids often retains the biological activity of the wild-type proteins.
Global substitution of canonical amino acids (cAAs) with noncanonical (ncAAs) counterparts in proteins whose function is dependent on post-translational events such as cofactor binding is still a methodically challenging and difficult task as ncAA insertion generally interferes with the cofactor biosynthesis machinery.
The global substitution of Pro with (4R -FPro enhanced the stability of the protein by −4R -FPromol−1, which is a conspicuous increnhancedstheility for a stabilityresidue profein like ubiquithe.
LCNS abundances shared between species were compared with the rate of silent substitution to test whether patterns of LCNS evolution are related to global substitution rates.
We investigated rates of non-synonymous and synonymous substitutions in coding regions of 4996 rodent orthologues, and found a global substitution rate bias associated with subterranean lineages.
The heterogeneous rate model r assumes a fraction θinv of sequence sites to be invariant, and other sites are variant with global substitution rates following the Γ-distribution [ 33].
CodR primers previously utilized by our laboratory for mtGenome sequencing [ 16- 20] were evaluated using the global alignment, substitution rate histogram, and Primer3 software [ 21], as described above.
Code readability and maintainability can frequently be enhanced through the use of mnemonic names and global text substitutions.
Based on these findings, we expect global amino acid substitution to significantly impair protein folding and function if this involves replacing multiple buried hydrophobic residues, although there is obviously also a potential for beneficial replacements [15].
Seven new codR amplicons were designed using the global alignment and substitution rate histogram.
For global alignment the substitution weight matrix PAM250 and gap-open and gap-extension penalties 14 and 2 were used; for local alignment the Gonnet250 matrix and penalties 10 and 0.5 were used.
