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A variety of radiographic grading systems have been proposed, but there is no single global staging system suitable for the assessment of OA at all sites.
In addition, a structured global staging instrument such as the GDS was used in the study to determine the severity stage of the patient for the use of the ROSA.
In further studies the performance of our molecular parameters in reflecting progression should be addressed in a longitudinal design, using other cognitive measures as well as global staging scales, such as the Clinical Dementia Rating Scale (CDR).
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