Sentence examples for global sensitization from inspiring English sources

We also found alterations in specific elements of the signaling cascade superimposed on global sensitization.

Indeed, global sensitization is likely to have widespread consequences in general because it affects all humoral signals that operate through cAMP, rather than involving any single input.

In the liver, where βARs and glucagon receptors are linked through AC to enhanced gluconeogenesis and lipolysis, global sensitization of AC signaling leads to corresponding metabolic abnormalities.

In the liver, DZN elicited global sensitization, characterized by parallel up-regulation of AC activity itself and of the responses to stimulants acting at β-adrenergic receptors, glucagon receptors, or G-proteins.

Indeed, we showed that neonatal CPF exposure dysregulates hepatic and cardiac AC (Meyer et al. 2004), with global sensitization of hepatic AC, augmenting the responses to multiple neurohumoral inputs and leading ultimately to metabolic abnormalities resembling those in prediabetes (Slotkin et al. 2005).

Here, we have employed tissue-specific deletion of GSK-3α, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3α KO animals.

Our aim is to study the global gene expression pattern induced by IgE sensitization and FcεRI aggregation on human mast cells.

Whereas the sensitivity can be explained by sensitization of the nervous system, the underlying causes of altered fecal output and reduced exploratory behavior remain to be determined and point to a global phenomenon affecting the organism as a whole rather than just a single system.

In contrast to DZN, neonatal PRT exposure produced a much larger initial sensitization of hepatic AC in adolescence, again involving global changes at the level of AC itself, but additional pathway effects were evident at the lower dose, reflecting smaller increments for glucagon and fluoride than for isoproterenol and forskolin.

This study is an attempt to elucidate the molecular mechanisms which mast cells undergo during "priming" IgE sensitization and full activation by FcεRI aggregation in a global perspective.

Having been established that the main driver of change in our Climate is the result of anthropogenic activities which contribute to the global increase in concentration of Green House Gases (GHG), there is therefore need for effective sensitization and public awareness regarding our actions and how they contribute to the issue of Climate Change experienced globally.