(3) Under some conditions, global quenching of propagating fronts could be observed as Ka increases above three hundred, well beyond the value at which gaseous flames quench.
Our "hybrid" UQ methodology supports independent development of the most suitable UQ method, intrusive or non-intrusive, for each physics module by providing an algorithmic framework to couple these "stochastic" modules for propagating "global" uncertainties.
Thereby cells may determine whether a given signal remains local or is converted into a propagating global signal.
These findings provide new insights into the mechanisms that cells may utilize to "filter" calcium signals via junctional complexes to determine whether a given signal remains local or is converted into a propagating global signal.
It is here that the spatial and temporal summation of coordinated Ca2+ release events from acidic organelles may be critical with respect to the conversion of NAADP-evoked quantal Ca2+ release into propagating, global Ca2+ waves via CICR from the S/ER and in a manner that may be determined by the threshold for activation by Ca2+ of IP3Rs and RyRs.
Thus the spatiotemporal integration of Ca2+ bursts may serve as a filter via which cellular signals may be sorted into either abortive local events or propagating global Ca2+ signals via lysosome-S/ER junctions (47, 48), analogous to the mitochondrial-S/ER junctions conferred by mitofusin 2-dependent interorganellar bridges (28).
Importantly, NAADP-dependent Ca 2+ bursts primarily arise from lysosomes in the perinuclear region of PASMCs and appear to promote rapid, local Ca 2+ transients that are of sufficient size to activate clusters of SR resident ryanodine receptor subtype 3 (RyR3) and thus initiate, in an all-or-none manner, a propagating global Ca 2+ wave.
The above mechanisms not only help keep the cytoplasmic Ca2+ level at bay so that any increase from basal levels can be read as a signal of metabolic or environmental change, but also limit the free diffusion of Ca2+ so that the Ca2+ signals remain local, unless a given threshold for initiation of a propagating, global Ca2+ wave is breached (30).
The inheritance of inverted ciliary rows reported by Beisson and Sonneborn, by contrast, is a clear-cut example of local information, in the form of the relation between mother and daughter centrioles, giving rise to a stably propagating global structure (the inverted ciliary row).
