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Orlando, D. A. et al. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.
Experimental evidence suggests that local impact of astrocytes on single synapses translates into global modulation of neuronal networks and behavior.
Observations of galactic Carbon in the heliosphere provide a useful tool with which a comprehensive description of the global modulation of cosmic rays both inside and outside off the solar wind termination shock (TS) can be made.
The model describing the connection between solar activity variation and cosmic ray convection diffusion global modulation for neutron monitor energies is here developed by taking into account also the time-lag of the small energy particle diffusion in the Heliosphere.
From comparisons with experimental data on long-term cosmic ray variation in cycle 22, we determine the role of convection-diffusion and drifts in global modulation, and the effective dimension of the modulation region.
We found that moving the termination shock from 90 to 100 AU, with the heliopause fixed at 120 AU, caused only quantitative differences so that the exact position of the TS in the outer heliosphere seems not crucially important to global modulation.
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As discussed above, other sensory recruitment processes have been shown to produce similar patterns of activity: feature-based attention, for example, can produce global modulations of measured V1 activity, even in the absence of visual stimulation [34], [54].
One method that is often used to control for such non-specific global modulations of signalling or vasculature reactivity by the drug is the inclusion of a control task to assess the BOLD response in a region that is not expected to be modulated by the drug, such as the visual stimulation paradigm used in this study.
Topf, U. et al. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
We obtain this important information on the basis of CR and SA data in the past, taking into account the theory of convection diffusion and global drift modulation of galactic CR in the Heliosphere.
Our initial findings also suggest the need for pressure studies with local cortical activation, rather than global CBF modulation.
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