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In networks of ontologies, inconsistency can come from two different sources: local inconsistency in a particular ontology or alignment, and global inconsistency between them.
This may explain why we observe local consistency between models at scales less than ∼15 years, but some degree of global inconsistency.
We find strong correspondence between our results and previous results by Smith et al. (2004), with equivalent models producing globally consistent antigenic maps and other models producing locally consistent maps with a small degree of global inconsistency (see 'Methods').
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Moreover, he's right to highlight global inconsistencies in regulation.
The COMA plugin cannot retrieve any of the multiple global inconsistencies we reported in Fig. 7.
The plugin outputs three types of results after checking for consistency: a list of local inconsistencies (LI), global inconsistencies (GI) or a list of predictions.
Using BioQuali, we obtained four types of results: local inconsistencies (LI), global inconsistencies (GI), only network consistency (Cons)., or predictions (Pred).. Using the COMA plugin only local inconsistencies are reported.
We also confronted the E. coli corrected regulatory model using the genome-scale compendium, obtaining 16 global inconsistencies between the model and the dataset when using 3-fold expression changes (see Fig. 7).
Project name: BioQualiPlugin Project home page: and Documentation and tutorial examples: Operating system(s): Platform independent Programming language: Java 5 License: CECILL version 2 (free open software) Users should contact [email protected] or [email protected] TFs: Transcription factors; SGE: Sun Grid Engine; LI: local inconsistencies; GI: global inconsistencies.
And when you're the head of a global superpower, inconsistency, unpredictability, those are dangerous things.
Micromanager syndrome; lack of local knowledge leads to poor adaptability fine sociological broad ecological No solutions for global problems, inconsistency and competition across regions Temporal scales long sociological short ecological Response times to slow short sociological long ecological Management decisions lack continuity and consistency, and limited consideration for the future.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com